Essays link Gaian science to such global environmental quandaries as climate change and biodiversity destruction, providing perspectives from science, ...

Gaia in Turmoil is the latest collaborative work put forth by the interdisciplinary group of Gaian thinkers. The contributors set out to meaningfully grapple with the bewildering ecological and social crises that humanity faces in this young century. Their work clearly rests on the assumption that such crises not only exist, but are dire—a conviction that unifies the essays in Gaia in Turmoil. By demonstrating how Gaia theory can advance various research projects, Gaia in Turmoil is an alarmist plea to (...) integrate the Gaian perspective into mainstream thought as the next watershed paradigm through which humanity can survive and prosper. (shrink)

Lateral temporal measures of the auditory evoked potential including the T-complex, as well as an earlier negative peak index maturation of auditory/speech processing. Previous studies have shown that these measures distinguish neural processing in children with typical language development from those with disorders and monolingual from bilingual children. In this study, bilingual children with Turkish as L1 and German as L2 were compared with monolingual German-speaking children with developmental language disorder and monolingual German-speaking children with TD in order to disentangle (...) effects of limited language input vs. reduced perceptual abilities in the processing of speech and non-speech stimuli. Sensory processing reflected by the T-complex was compared in response to a German vowel and a sine-wave tone in the three groups of children, ages 5 through 6 years. Stimuli were presented while children watched a muted video. Auditory evoked potentials were time-locked to the vowels and tones. AEPs to the frequent stimuli within an oddball paradigm were analyzed at the left and right temporal electrode sites.The results revealed language status, stimulus, and language test measures all influenced the T-complex amplitudes. Particularly, the peak amplitude of Ta was modulated by language status and stimulus type. Bilingual children had significantly more negative Ta responses than the monolingual children with TD for both vowels and tones while DLD children differed from TD children only for the vowel stimulus. The amplitude of the T-complex was overall more negative at the left than at the right site. The Na peak latency was longer for the bilingual group than that observed for the two monolingual groups. The Tb latency was shorter for DLD and bilingual groups than that for TD children in the vowel condition, but no such latency difference between DLD and bilingual children was found. We suggest that the attenuated T-complex for bilingual children indicates continued plasticity of the auditory cortex to allow for learning of novel, second-language speech sounds. (shrink)

The current paper synthesizes theory and data from the field of life history (LH) evolution to advance a new developmental theory of variation in human LH strategies. The theory posits that clusters of correlated LH traits (e.g., timing of puberty, age at sexual debut and first birth, parental investment strategies) lie on a slow-to-fast continuum; that harshness (externally caused levels of morbidity-mortality) and unpredictability (spatial-temporal variation in harshness) are the most fundamental environmental influences on the evolution and development of LH (...) strategies; and that these influences depend on population densities and related levels of intraspecific competition and resource scarcity, on age schedules of mortality, on the sensitivity of morbidity-mortality to the organism’s resource-allocation decisions, and on the extent to which environmental fluctuations affect individuals versus populations over short versus long timescales. These interrelated factors operate at evolutionary and developmental levels and should be distinguished because they exert distinctive effects on LH traits and are hierarchically operative in terms of primacy of influence. Although converging lines of evidence support core assumptions of the theory, many questions remain unanswered. This review demonstrates the value of applying a multilevel evolutionary-developmental approach to the analysis of a central feature of human phenotypic variation: LH strategy. (shrink)

The essays in this book discuss the originally proposed Baldwin effect, how it was modified over time, and its possible contribution to contemporary empirical...

"... the most important contribution to Kierkegaard studies to be published in English in recent years.... Not only is it a fascinating, surprising, and perceptive study of Kierkegaard within his time and world, Kirmmse has produced a research resource, a reference work, that is simply without parallel or equal." —Michael Plekon "It is a rare work of philosophy that not only clarifies its subject but also places it within an intellectual and historical context. In his study of 19th-century Danish philosopher (...) Kierkegaard, Kirmmse accomplishes both, setting a standard... " —Library Journal "... an outstanding contribution to Kierkegaard research... The book is intellectual history of the highest calibre." —So[slash]ren Kierkegaard Newsletter "This excellent book is recommended for all collections on Kierkegaard... For all readers." —Choice "This richly researched and readable book supplies an important contribution to the widespread reappropriation of Kierkegaard’s thought currently taking place."—Theology Today "This book is a tour de force in intellectual history." —Review of Metaphysics "Kirmmse's book is a major work of scholarship that confers on Kierkegaard's social and intellectual universe a depth and a richness of detail that will permanently alter the familiar stereotypes about Kierkegaard's isolation from his fellow Danes and his supposedly fanatical campaign against philistine Denmark and its corrupt state church." —American Historical Review Against the background of Denmark’s evolution from a mercantile economy to a broad-based agricultural economy, Kirmmse reinterprets Kierkegaard’s thought as a reaction to the tensions within his society. (shrink)

Innovation is fundamental to cumulative culture, allowing progressive modification of existing technology. The authors define innovation as an asocial process, uninfluenced by social information. We argue that innovation is inherently social – innovation is frequently the product of modifying others' outputs, and successful innovations are acquired by others. Research should target examination of the cognitive underpinnings of socially-mediated innovations.

We trace the history of the Modern Evolutionary Synthesis, and of genetic Darwinism generally, with a view to showing why, even in its current versions, it can no longer serve as a general framework for evolutionary theory. The main reason is empirical. Genetical Darwinism cannot accommodate the role of development (and of genes in development) in many evolutionary processes. We go on to discuss two conceptual issues: whether natural selection can be the “creative factor” in a new, more general framework (...) for evolutionary theorizing; and whether in such a framework organisms must be conceived as self-organizing systems embedded in self-organizing ecological systems. (shrink)

Physicists and historians of science have always held that Isaac Newton should receive credit for the first proof that inverse-square orbits must be conics. This conviction derives from a brief argument, regarded as essentially correct, given by Newton in the Principia. Recently, however, it has been contended that this outline or sketch contains irreparable logical flaws. Here, the logical structure of this outline of Newton's, as well as the details that this outline omits, are carefully examined. We find that whilst (...) his argument does indeed contain a flaw, it is a minor omission rather than a serious logical error. Having rectified this omission, we show how Newton's outline expands into a convincing proof that inverse-square orbits must be conics. (shrink)

Using the evolution of the stickleback family of subarctic fish as a touchstone, we explore the effect of new discoveries about regulatory genetics, developmental plasticity, and epigenetic inheritance on the conceptual foundations of the Modern Evolutionary Synthesis. Identifying the creativity of natural selection as the hallmark of the Modern Synthesis, we show that since its inception its adherents have pursued a variety of research projects that at first seemed to conflict with its principles, but were accommodated. We situate challenges coming (...) from developmental biology in a dialectic between innovation and tradition, suggesting on the basis of past episodes that even if developmental plasticity and epigenetic inheritance are aligned with its principles the Modern Synthesis will be significantly affected. (shrink)

The Darwinian concept of natural selection was conceived within a set of Newtonian background assumptions about systems dynamics. Mendelian genetics at first did not sit well with the gradualist assumptions of the Darwinian theory. Eventually, however, Mendelism and Darwinism were fused by reformulating natural selection in statistical terms. This reflected a shift to a more probabilistic set of background assumptions based upon Boltzmannian systems dynamics. Recent developments in molecular genetics and paleontology have put pressure on Darwinism once again. Current work (...) on self-organizing systems may provide a stimulus not only for increased problem solving within the Darwinian tradition, especially with respect to origins of life, developmental genetics, phylogenetic pattern, and energy-flow ecology, but for deeper understanding of the very phenomenon of natural selection itself. Since self-organizational phenomena depend deeply on stochastic processes, self-organizational systems dynamics advance the probability revolution. In our view, natural selection is an emergent phenomenon of physical and chemical selection. These developments suggest that natural selection may be grounded in physical law more deeply than is allowed by advocates of the autonomy of biology, while still making it possible to deny, with autonomists, that evolutionary explanations can be modeled in terms of a deductive relationship between laws and cases. We explore the relationship between, chance, self-organization, and selection as sources of order in biological systems in order to make these points. (shrink)

This book explores the puzzling phenomenon of new veiling practices among lower middle class women in Cairo, Egypt.

The three cycles of cell division immediately following theformation of the cellular blastoderm during Drosophila embryogenesis display an invariant pattern(1,2). Bursts of transcription of a gene called string are required and sufficient to trigger mitosis at this time during development(3). The activator of mitosis encoded by the string gene is a positive regulator of cdc2 kinase and a Drosophila homologue of the Saccharomyces pombe cdc25 tyrosine phosphatase(4,5). Evidence presented in a recent paper(6) demonstrates that transcription of string, and hence the (...) timing and pattern of mitosis in the postblastoderm embryo, is under complex developmental control. Several lines of evidence support this interpretation, including the analysis of string transcription in pattern formation mutants, cell cycle arrest mutants, and the preliminary characterization of an extensive cis‐acting regulatory region. (shrink)

We identify two aspects of the problem of maintaining perceptual stability despite an observer's eye movements. The first, visual direction constancy, is the (egocentric) stability of apparent positions of objects in the visual world relative to the perceiver. The second, visual position constancy, is the (exocentric) stability of positions of objects relative to each other. We analyze the constancy of visual direction despite saccadic eye movements.Three information sources have been proposed to enable the visual system to achieve stability: the structure (...) of the visual field, proprioceptive inflow, and a copy of neural efference or outflow to the extraocular muscles. None of these sources by itself provides adequate information to achieve visual direction constancy; present evidence indicates that all three are used.Our final question concerns how information processing operations result in a stable world. The three traditionally suggested means have been elimination, translation, or evaluation. All are rejected. From a review of the physiological and psychological evidence we conclude that no subtraction, compensation, or evaluation need take place. The problem for which these solutions were developed turns out to be a false one. We propose a “calibration” solution: correct spatiotopic positions are calculated anew for each fixation. Inflow, outflow, and retinal sources are used in this calculation: saccadic suppression of displacement bridges the errors between these sources and the actual extent of movement. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:A Chance to CutBruce H. CampbellMy gloved hand reaches for progressively sharper surgical instruments. The prior radiation therapy and recurrent cancer [End Page E3] have made his neck tissues as stiff and hard as an old block of wood; everything appears too dull and feels too dry under the bright operating room lights. I push, dissect, urge, divide, prod, and spread with little effect.The nursing staff keeps to its (...) routine—completing computer entries, retrieving supplies, counting sponges—only intermittently aware that things are not going well at the point of attack. Nondescript music plays softly and the anesthesia machine continues to emit its gentle sounds. The junior resident—assisting me with the first of many neck dissections she will see during her five years of training—grips the retractor as she has been told and dabs the wound periodically to clear any blood or fluid.I glance up to recheck the CT scan. It confirms that this man’s recurrent cancer is just below the next layer of neck muscles. There are also some large blood vessels and major nerves nearby. I am confident, though, that I will be able to expose the mass, protect all of the critical structures, and safely remove the cancer.Curing cancer with surgery is no small feat, mind you. Cancer is, after all, a molecular disease not easily confined to an obvious lump, even though we sometimes refer to a malignant mass being “like a walnut” or “as hard and round as a marble.” The actual disease rests deep inside each cancer cell where the genetic code—the DNA—makes mistake–after–mistake. If cancer is to be cured with a surgical procedure, the surgeon must remove every last cell that is capable of making the same nonsensical, life–threatening error. Given Science’s rudimentary knowledge of cancer cell dynamics and signaling, it’s a miracle that surgery ever works. Yet, we continue to try. And we succeed just often enough to keep on trying.I rearrange the retractors and alter my approach. My mentors would have known what to do next, I imagine. My training included time well–spent with brilliant and technically–gifted surgeons. How would they have approached this case? Their experience and instincts might have told them to open the wound more widely, work the lateral and deep margins first, or position the instruments differently.Perhaps, one of my mentors would have attacked this man’s tumor using the same approach I am attempting but would have known exactly where to exploit some area of weakness that I cannot locate. A few swift, confident moves and he would have held the mass in his hands. “That’s it. We’re done,” he would have said.I met this patient several months ago when his cancer was first discovered and have seen him throughout his course of treatment. Recently, his daughter had accompanied him to the office to review his options. “Treatment has been rugged, Doc,” he reminded me. “The cancer’s still there and they said I can’t get any more radiation. Chemo would only prolong things. I don’t really want surgery, but what choice do I have if I want to be cured?”“Supportive care is an option, but the only curative approach is surgery.”“Well, I’m not ready to quit yet, Doc. I got grand-kids, y’know. I want to watch them grow up.” He nodded to his daughter. “I’m in charge of spoiling her little boys.”The daughter smiled. We crowded around the computer screen to look at the scans. I showed them how the tumor was invading and destroying surrounding structures. I described the surgery and the risks.“There are many things I will not know about your tumor until we are actually in the operating room,” I explained. Surgery in the setting of recurrent disease involves a series of on–the–spot decisions and course corrections. The odds of success are unknowable. “Sometimes, the only way to find out if we can remove the cancer is simply to try.”He took a deep breath and looked at his daughter. “Well then, Doc, if surgery is the only... (shrink)

The spectacular “attack upon Christendom” with which Kierkegaard concluded his career (and his life) was not an aberration. It was the culmination of an anticlerical---and, indeed, antiecclesial---tendency that had developed over a considerable period. This development can be followed quite clearly in Kierkegaard’s journals and papers, where we can observe Kierkegaard’s stance as it evolved through his often polemical engagement with the leading ecclesiastical figures of his time, and in particular with Bishop J. P. Mynster, Primate of the Danish Church. (...) Of even greater importance, we can observe Kierkegaard’s increasing appreciation of the significance of the modernizing Revolution of 1848, particularly the ecclesiastical and political consequences of that revolution. But Kierkegaard’s critique also worked its way backward in time from 1848, and in the end it is doubtful whether he viewed any form of earthly congregation as compatible with what he believed to be “the Christianity of the New Testament.”. (shrink)

If the problem of the origin of life is conceptualized as a process of emergence of biochemistry from proto-biochemistry, which in turn emerged from the organic chemistry and geochemistry of primitive earth, then the resources of the new sciences of complex systems dynamics can provide a more robust conceptual framework within which to explore the possible pathways of chemical complexification leading to living systems and biosemiosis. In such a view the emergence of life, and concomitantly of natural selection and biosemiosis, (...) is the result of deep natural laws (the outlines of which we are only beginning to perceive) and reflects a degree of holism in those systems that led to life. Further, such an approach may lead to the development of a more general theory of biology and of natural organization, one informed by semiotic concepts. (shrink)

The design argument was rebutted by David Hume. He argued that the world and its contents (such as organisms) were not analogous to human artifacts. Hume further suggested that there were equally plausible alternatives to design to explain the organized complexity of the cosmos, such as random processes in multiple universes, or that matter could have inherent properties to self-organize, absent any external crafting. William Paley, writing after Hume, argued that the functional complexity of living beings, however, defied naturalistic explanations. (...) In effect he dared anyone to come up with an alternative to his inference to design, and hence a designer, outside of nature. Charles Darwin explained the apparent design of functional complexity by his theory of natural selection. Asa Gray, however, in essays as well as in correspondence with Darwin argued that natural selection allowed for a type of ' evolutionary teleology' in which design at most could be considered the result of universal principles. F. E. Hicks updated Hume by specifically objecting to the use of design arguments by Paley. Hicks argued that the apparent design seen in nature reflected order at a deep level in nature. The design argument was briefly revived by Lawrence Henderson early in the twentieth century but he ultimately concluded that design and teleology were not necessarily mutually entailing and he retracted his design argument in favor of one that he termed ' natural teleology'. The current claims of ' intelligent design' have the same logical problems that have beset previous design arguments. If design is divorced from teleology and its discontents put behind us, then there is a possibility that the latter can have a place in the development of theories to explain the phenomena of emergent complexity. (shrink)

The autocell proposal for the emergence of life and natural selection through the interaction of two reciprocally coupled self-organizing processes specifically provides a protein-first model for the origin of life that can be explored by computer simulations and experiment. Beyond the specific proposal it can be considered more generally as a thought experiment in which the principles deduced for the autocell could apply to other possible detailed chemical scenarios of catalytic polymers and protometabolism, including living systems emerging within membranelike barriers. (...) The autocell model allows for the analysis of the emergence of not only agency and purpose but also of interpretation and semiosis as true living systems arise. (shrink)

The spectacular “attack upon Christendom” with which Kierkegaard concluded his career (and his life) was not an aberration. It was the culmination of an anticlerical---and, indeed, antiecclesial---tendency that had developed over a considerable period. This development can be followed quite clearly in Kierkegaard’s journals and papers, where we can observe Kierkegaard’s stance as it evolved through his often polemical engagement with the leading ecclesiastical figures of his time, and in particular with Bishop J. P. Mynster, Primate of the Danish Church. (...) Of even greater importance, we can observe Kierkegaard’s increasing appreciation of the significance of the modernizing Revolution of 1848, particularly the ecclesiastical and political consequences of that revolution. But Kierkegaard’s critique also worked its way backward in time from 1848, and in the end it is doubtful whether he viewed any form of earthly congregation as compatible with what he believed to be “the Christianity of the New Testament.”. (shrink)

The design argument was rebutted by David Hume. He argued that the world and its contents (such as organisms) were not analogous to human artifacts. Hume further suggested that there were equally plausible alternatives to design to explain the organized complexity of the cosmos, such as random processes in multiple universes, or that matter could have inherent properties to self-organize, absent any external crafting. William Paley, writing after Hume, argued that the functional complexity of living beings, however, defied naturalistic explanations. (...) In effect he dared anyone to come up with an alternative to his inference to design, and hence a designer, outside of nature. Charles Darwin explained the apparent design of functional complexity by his theory of natural selection. Asa Gray, however, in essays as well as in correspondence with Darwin argued that natural selection allowed for a type of ‘evolutionary teleology’ in which design at most could be considered the result of universal principles. F.E. Hicks updated Hume by specifically objecting to the use of design arguments by Paley. Hicks argued that the apparent design seen in nature reflected order at a deep level in nature. The design argument was briefly revived by Lawrence Henderson early in the twentieth century but he ultimately concluded that design and teleology were not necessarily mutually entailing and he retracted his design argument in favor of one that he termed ‘natural teleology’. The current claims of ‘intelligent design’ have the same logical problems that have beset previous design arguments. If design is divorced from teleology and its discontents put behind us, then there is a possibility that the latter can have a place in the development of theories to explain the phenomena of emergent complexity. (shrink)

Transcranial magnetic stimulation was used to test the functional role of parietal and prefrontal cortical regions activated during a playing card Guilty Knowledge Task. Single-pulse TMS was applied to 15 healthy volunteers at each of three target sites: left and right dorsolateral prefrontal cortex and midline parietal cortex. TMS pulses were applied at each of five latencies after the onset of a card stimulus. TMS applied to the parietal cortex exerted a latency-specific increase in inverse efficiency score and in reaction (...) time when subjects were instructed to lie relative to when asked to respond with the truth, and this effect was specific to when TMS was applied at 240 ms after stimulus onset. No effects of TMS were detected at left or right DLPFC sites. This manipulation with TMS of performance in a deception task appears to support a critical role for the parietal cortex in intentional false responding, particularly in stimulus selection processes needed to execute a deceptive response in the context of a GKT. However, this interpretation is only preliminary, as further experiments are needed to compare performance within and outside of a deceptive context to clarify the effects of deceptive intent. (shrink)

This chapter examines the role of Soren Kierkegaard in the so-called Danish Golden Age from 1800 to 1850, which was marked by a remarkable outpouring of artistic, scientific, literary, philosophical, and theological productivity. It explains that Kierkegaard, together with Hans Christian Andersen, belongs to the third generation of this Golden Age. The chapter considers the major works of Kierkegaard and Andersen, who were the two most prominent figures of the Golden Age both in and outside Denmark.

For over a century, the Danish thinker Søren Kierkegaard has been at the center of a number of important discussions, concerning not only philosophy and theology, but also, more recently, fields such as social thought, psychology, and contemporary aesthetics, especially literary theory. Despite his relatively short life, Kierkegaard was an extraordinarily prolific writer, as attested to by the 26-volume Princeton University Press edition of all of his published writings. But Kierkegaard left behind nearly as much unpublished writing, most of which (...) consists of what are called his "journals and notebooks." Kierkegaard has long been recognized as one of history's great journal keepers, but only rather small portions of his journals and notebooks are what we usually understand by the term "diaries." By far the greater part of Kierkegaard's journals and notebooks consists of reflections on a myriad of subjects--philosophical, religious, political, personal. Studying his journals and notebooks takes us into his workshop, where we can see his entire universe of thought. We can witness the genesis of his published works, to be sure--but we can also see whole galaxies of concepts, new insights, and fragments, large and small, of partially completed but unpublished works. Kierkegaard's Journals and Notebooks enables us to see the thinker in dialogue with his times and with himself. Volume 6 of this 11-volume series includes four of Kierkegaard's important "NB" journals, covering the months from early May 1849 to the beginning of 1850. At this time Denmark was coming to terms with the 1848 revolution that had replaced absolutism with popular sovereignty, while the war with the German states continued, and the country pondered exactly what replacing the old State Church with the Danish People's Church would mean. In these journals Kierkegaard reflects at length on political and, especially, on ecclesiastical developments. His brooding over the ongoing effects of his fight with the satirical journal Corsair continues, and he also examines and re-examines the broader personal and religious significance of his broken engagement with Regine Olsen. These journals also contain reflections by Kierkegaard on a number of his most important works, including the two works written under his "new" pseudonym Anti-Climacus and his various attempts at autobiographical explanations of his work. And, all the while, the drumbeat of his radical critique of "Christendom" continues and escalates. Kierkegaard wrote his journals in a two-column format, one for his initial entries and the second for the extensive marginal comments that he added later. This edition of the journals reproduces this format, includes several photographs of original manuscript pages, and contains extensive scholarly commentary on the various entries and on the history of the manuscripts being reproduced. (shrink)

I would like to write a novel in which the main character would be a man who got a pair of glasses, one lens of which reduced images as powerfully as an oxyhydrogen microscope, and the other of which magnified on the same scale, so that he perceived everything relatively. A flight of fancy by an aspiring science fiction writer? While it may sound as such, this wistful musing is one of the little-discussed personal reflections of nineteenth-century philosopher Søren Kierkegaard, (...) whose remarkable journals and notebooks, unpublished during his lifetime, are presented here. The first of an eleven-volume series produced by Copenhagen's Søren Kierkegaard Research Centre, this volume is the first English translation and commentary of Kierkegaard's journals based on up-to-date scholarship. It offers new insight into Kierkegaard's inner life. In addition to early drafts of his published works, the journals contain his thoughts on current events and philosophical and theological matters, notes on books he was reading, miscellaneous jottings, and ideas for future literary projects. Kierkegaard wrote his journals in a two-column format, one for his initial entries and the second for the marginal comments he added later. The new edition of the journals reproduces this format and contains photographs of original manuscript pages, as well as extensive scholarly commentary. Translated by leading experts on Kierkegaard, Journals and Notebooks will become the benchmark for all future Kierkegaard scholarship. (shrink)

"The day will come when not only my writings, but precisely my life--the intriguing secret of all the machinery--will be studied and studied." Søren Kierkegaard's remarkable combination of genius and peculiarity made this a fair if arrogant prediction. But Kierkegaard's life has been notoriously hard to study, so complex was the web of fact and fiction in his work. Joakim Garff's biography of Kierkegaard is thus a landmark achievement. A seamless blend of history, philosophy, and psychological insight, all conveyed with (...) novelistic verve, this is the most comprehensive and penetrating account yet written of the life and works of the enigmatic Dane who changed the course of intellectual history. Garff portrays Kierkegaard not as the all-controlling impresario behind some of the most important works of modern philosophy and religious thought--books credited with founding existentialism and prefiguring postmodernism--but rather as a man whose writings came to control him. Kierkegaard saw himself as a vessel for his writings, a tool in the hand of God, and eventually as a martyr singled out to call for the end of "Christendom." Garff explores the events and relationships that formed Kierkegaard, including his guilt-ridden relationship with his father, his rivalry with his brother, and his famously tortured relationship with his fiancée Regine Olsen. He recreates the squalor and splendor of Golden Age Copenhagen and the intellectual milieu in which Kierkegaard found himself increasingly embattled and mercilessly caricatured. Acclaimed as a major cultural event on its publication in Denmark in 2000, this book, here presented in an exceptionally crisp and elegant translation, will be the definitive account of Kierkegaard's life for years to come. (shrink)